Glutathione 600mg*10vials

4. Application in the prevention and treatment of eye diseases

Prevention and treatment of cataracts: In ophthalmology, glutathione can be used for the prevention and treatment of cataracts. Research shows that the occurrence of cataracts is closely related to oxidative damage in the lens. As an antioxidant, glutathione can reduce the impact of oxidative damage on lens cells and maintain the normal function of the lens. For example, in a study, eye drops containing glutathione were used to treat cataract patients, and it was observed that the degree of lens opacity of the patients was reduced, and their vision was improved to a certain extent ^[9].

Prevention and treatment of retinopathy: Retinopathy is a common eye disease, and its occurrence is related to factors such as oxidative stress and inflammatory response. Glutathione can, through its antioxidant effect, reduce the oxidative damage of the retinal tissue, inhibit the inflammatory response, and thus protect retinal cells. In addition, glutathione can also promote the metabolic function of retinal cells and enhance the self-repair ability of the retina^[9].

5. Application in multiple sclerosis

In multiple sclerosis, neuronal degeneration is related to oxidative stress. Dimethyl fumarate (DMF) is an effective oral treatment option that has been proven to reduce disease activity and progression in patients with relapsing-remitting multiple sclerosis. DMF can activate the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), leading to an increase in the synthesis of the main cellular antioxidant glutathione (GSH), and has a significant neuroprotective effect in vitro. Studies have found that DMF does induce glutathione reductase (GSR), increasing the recycling of glutathione by inducing GSR^[10].

6. Application in Alzheimer’s disease

In Alzheimer’s disease, amyloid β peptide (Aβ) is considered one of the important causes of Alzheimer’s disease (AD). Ferroptosis is a newly recognized mechanism of oxidative cell death that is highly related to AD. Tetrahydroxystilbene glucoside (TSG) is beneficial in relieving learning and memory in AD and aged mouse models. Studies have found that TSG resists the neurotoxic death of nerve cells caused by Aβ by regulating ferroptosis-related proteins and enzymes in APP/PS1 mice, alleviates cellular oxidative stress and inflammatory damage, and promotes the activation of the GSH/GPX4/ROS and Keap1/Nrf2/ARE signaling pathways. In addition, TSG also reduces the expression of markers related to ferroptosis and enhances the ability to resist oxidative stress ^[11].

7. Adjuvant treatment of respiratory diseases

Adjuvant treatment of chronic obstructive pulmonary disease (COPD): For patients with chronic obstructive pulmonary disease, airway inflammation and oxidative stress are important factors leading to the progression of the disease. Glutathione can alleviate airway inflammation and improve respiratory function through its antioxidant effect. It can scavenge free radicals in the airway, reduce the damage of oxidative stress to airway epithelial cells, and thus relieve airway inflammation. In addition, glutathione can also regulate immune function and enhance the body’s resistance to pathogens ^[12].

8. Application in islet diseases

The glutathione reductase and glutathione peroxidase were evaluated in the serum of patients with islet diseases and diabetic patients. Research shows that in this disease, the imbalance of the ratio of oxidants to antioxidants may be related to the condition, and the specific mechanism remains to be further studied^[13].

Conclusions

As a tripeptide compound composed of glutamic acid, cysteine, and glycine, glutathione plays a variety of key roles in living organisms, such as antioxidation, detoxification, immune regulation, and influence on the reproductive system. Since its discovery, with the deepening of research, its application value in the medical field has been continuously highlighted, showing positive effects in the treatment or prevention of a variety of diseases such as alcoholic liver disease, Parkinson’s disease, cardiovascular diseases, and eye diseases. Although the application mechanisms in some aspects and the details of its roles in certain diseases remain to be further explored, glutathione is of great significance in maintaining the health of the body and preventing and treating diseases.

Scientific Journal Author

Rom O is an accomplished researcher affiliated with several prestigious institutions, including the Louisiana State University Health Sciences Center at Shreveport, Louisiana State University System, University of Pittsburgh, and University of Michigan. His work has been associated with notable entities such as Lsuhs Shreveport and Michigan Med, reflecting his active involvement in significant academic and medical environments.

Rom O’s research interests span across a wide array of subject categories. His expertise lies in the fields of the Cardiovascular System & Cardiology, Hematology, Endocrinology & Metabolism, Biochemistry & Molecular Biology, and Gastroenterology & Hepatology. With a career focused on these intricate areas of study, he has contributed to the advancement of knowledge and understanding in these critical branches of medical science.is listed in the reference of citation [9].

▎Relevant Citations

[1]  Reddy V N. Glutathione and its function in the lens-an overview.[J]. Experimental Eye Research, 1990,50(6):771-778.DOI:10.1016/0014-4835(90)90127-G.

[2]  Abnousian A, Vasquez J, Sasaninia K, et al. Glutathione Modulates Efficacious Changes in the Immune Response against  Tuberculosis[J]. Biomedicines, 2023,11(5).DOI:10.3390/biomedicines11051340.

[3]  Ogunfolaju E. Glutathione[M]. 2020.https://www.researchgate.net/publication/344526535_Glutathione.

[4]  Ck D A. Intravenous Glutathione: A Promising Therapy for the Alcoholic Liver Disease[J]. Journal of Medical Science and Clinical Research, 2024.

[5]  Weschawalit S, Thongthip S, Phutrakool P, et al. Glutathione and its antiaging and antimelanogenic effects[J]. Clinical Cosmetic and Investigational Dermatology, 2017,10:147-153.DOI:10.2147/CCID.S128339.

[6]  Wang H, Zhang J, Li Y, et al. Potential use of glutathione as a treatment for Parkinson’s disease[J]. Experimental and Therapeutic Medicine, 2021,21(2):125.DOI:10.3892/etm.2020.9557.

[7]  Matuz-Mares D, Riveros-Rosas H, Vilchis-Landeros M M, et al. Glutathione Participation in the Prevention of Cardiovascular Diseases[J]. Antioxidants, 2021,10(8).DOI:10.3390/antiox10081220.

[8]  Rom O, Liu Y, Finney A C, et al. Induction of glutathione biosynthesis by glycine-based treatment mitigates  atherosclerosis[J]. Redox Biology, 2022,52:102313.DOI:10.1016/j.redox.2022.102313.

[9]  Ganeshpurkar A, Bhadoriya S S, Pardhi P, et al. In vitro prevention of cataract by Oyster Mushroom Pleurotus florida extract on  isolated goat eye lens[J]. Indian Journal of Pharmacology, 2011,43(6):667-670.DOI:10.4103/0253-7613.89823.

[10] Hoffmann C, Dietrich M, Herrmann A, et al. Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase[J]. Oxidative Medicine and Cellular Longevity, 2017,2017.DOI:10.1155/2017/6093903.

[11] Gao Y, Li J, Wu Q, et al. Tetrahydroxy stilbene glycoside ameliorates Alzheimer’s disease in APP/PS1 mice  via glutathione peroxidase related ferroptosis[J]. International Immunopharmacology, 2021,99:108002.DOI:10.1016/j.intimp.2021.108002.

[12] Dewan B, Shinde S. Glutathione an Effective Adjuvant Therapy for Acute Respiratory Distress Syndrome Associated with COVID-19 Infection[J]. Journal of Advances in Medicine and Medical Research, 2022.DOI: https://doi.org/10.4103/jrms.jrms_777_20.

[13] Khaki L, Vaezi G, Ayatollahi A, et al. Evaluation of Glutathione Reductase and Glutathione Peroxidase in the Serum of Iranian Patients with Alopecia Areata: A Case-control Study[J]. Iranian Journal of Allergy Asthma and Immunology, 2020,19(6):676-678.DOI:10.18502/ijaai.v19i6.4937.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE SOLELY FOR INFORMATION DISSEMINATION AND EDUCATIONAL PURPOSES.  

The products provided on this website are intended exclusively for in vitro research. In vitro research (Latin: *in glass*, meaning in glassware) is conducted outside the human body. These products are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and must not be used to prevent, treat, or cure any medical condition, disease, or ailment. It is strictly prohibited by law to introduce these products into the human or animal body in any form.